🩸 HIGH-YIELD TOPIC: DISSEMINATED INTRAVASCULAR COAGULATION (DIC) 🩸 Highly important for Critical Care nursing sections. This is a complex "secondary" disorder. 📌 WHAT IS DIC? A life-threatening condition where the body's clotting mechanism breaks down. 👉 Paradox: Massive clotting occurs first, followed by massive bleeding. 👉 It is NOT a primary disease: It is always a complication of another condition (Sepsis, Trauma, Abruptio Placentae). 📌 PATHOPHYSIOLOGY Trigger (Sepsis/Trauma) → Excessive Thrombin generation → Widespread Micro-clots in capillaries → Depletion of Clotting Factors & Platelets → UNCONTROLLED BLEEDING. 📍 Key point: Organ failure happens because micro-clots block blood flow to kidneys, lungs, and brain. 📌 CAUSES (THE "TRIGGERS") 🔹 Sepsis: Most common cause (especially Gram-negative). 🔹 Obstetric Complications: Abruptio Placentae, Amniotic fluid embolism. 🔹 Major Trauma/Burns. 🔹 Cancer: Acute Leukemia. 🔹 Incompatible Bl...
🩸 HIGH-YIELD TOPIC: DISSEMINATED INTRAVASCULAR COAGULATION (DIC) 🩸 Highly important for Critical Care nursing sections. This is a complex "secondary" disorder. 📌 WHAT IS DIC? A life-threatening condition where the body's clotting mechanism breaks down. 👉 Paradox: Massive clotting occurs first, followed by massive bleeding. 👉 It is NOT a primary disease: It is always a complication of another condition (Sepsis, Trauma, Abruptio Placentae). 📌 PATHOPHYSIOLOGY Trigger (Sepsis/Trauma) → Excessive Thrombin generation → Widespread Micro-clots in capillaries → Depletion of Clotting Factors & Platelets → UNCONTROLLED BLEEDING. 📍 Key point: Organ failure happens because micro-clots block blood flow to kidneys, lungs, and brain. 📌 CAUSES (THE "TRIGGERS") 🔹 Sepsis: Most common cause (especially Gram-negative). 🔹 Obstetric Complications: Abruptio Placentae, Amniotic fluid embolism. 🔹 Major Trauma/Burns. 🔹 Cancer: Acute Leukemia. 🔹 Incompatible Bl...