🩸 HIGH-YIELD TOPIC: DISSEMINATED INTRAVASCULAR COAGULATION (DIC) 🩸 Highly important for Critical Care nursing sections. This is a complex "secondary" disorder. 📌 WHAT IS DIC? A life-threatening condition where the body's clotting mechanism breaks down. 👉 Paradox: Massive clotting occurs first, followed by massive bleeding. 👉 It is NOT a primary disease: It is always a complication of another condition (Sepsis, Trauma, Abruptio Placentae). 📌 PATHOPHYSIOLOGY Trigger (Sepsis/Trauma) → Excessive Thrombin generation → Widespread Micro-clots in capillaries → Depletion of Clotting Factors & Platelets → UNCONTROLLED BLEEDING. 📍 Key point: Organ failure happens because micro-clots block blood flow to kidneys, lungs, and brain. 📌 CAUSES (THE "TRIGGERS") 🔹 Sepsis: Most common cause (especially Gram-negative). 🔹 Obstetric Complications: Abruptio Placentae, Amniotic fluid embolism. 🔹 Major Trauma/Burns. 🔹 Cancer: Acute Leukemia. 🔹 Incompatible Bl...
Here is the extracted text from the image: Section 7: Abnormalities of Pregnancy, Labor and Puerperium AMNIOTIC FLUID EMBOLISM This condition occurs when amniotic fluid enters the maternal circulation through a tear in the membranes or placenta. The body responds in two phases—The initial phase is one of vasospasm causing hypoxia, hypotension and cardiovascular collapse. The second phase is the development of left ventricular failure, with hemorrhage and coagulation disorder followed by pulmonary edema. Mortality and morbidity are very high. The presence of thromboplastin rich liquor amnii in the maternal circulation blocks the pulmonary arteries and triggers the complex coagulation mechanism leading to DIC. There will be severe clotting defect with profuse bleeding per vagina or through the venepuncture sites due to consumption of coagulation factors. Predisposing Factors Amniotic fluid embolism can occur at any stage in gestation. It is mostly associated with labor, though ...